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KMID : 0616619990050020205
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Journal of Soonchunhyang Medical College
1999 Volume.5 No. 2 p.205 ~ p.210
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The Effect of Angiotensin on Renovascular Response to Norepinephrine
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Abstract
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To determine the effect of angiotensin Ⅱ(ANG Ⅱ)-induced hypertension on the renal hemodynamic response of norepinephrine(NE), mongrel dog instrumented for checking of renal blood flow(RBF) was followed as the step increases every 2 minutes in the rate of norepinephrine infusion into the renal artery during 5 conditions (C : control, C+PD : control+pressure decompression of aorta, ACEI : angiotensin converting enzyme inhibitor, ACEI+ANG Ⅱ : angiotensin converting enzyme inhibitor+ANG Ⅱ, ACEI+ANG Ⅱ+PD : angiotensin converting enzyme inhibitor+ANG Ⅱ+pressure decompression of aorta) Without relation of increase (C, C+PD) or decrease (ACEI+ANG Ⅱ, ACEI+ANG Ⅱ+PD) of the plasma ANG Ⅱ level when NE is infused into vessel, there were no differences in RBF response to NE infusion between C and C+PD and between ACEI+ANG Ⅱ and ACEI+ANG Ⅱ+PD, which implies that renal arterial pressure(RAP) does not play an important role in controling the renal hemodynamic response to NE. When renin angiotensin system was blocked by captopril without adding to ANG Ⅱ supply (ACEI), RBF can be severe decreased to approximately 90% at much lower rates of NE infusion than occurred when the sufficient concentration of ANG Ⅱ were present in the plasma.
As the increased sensitivity of NE did not occur at lower renal arterial pressure, when ANGⅡ was present in the plasma in sufficient concentrations, it seems that protective effect on renal function is possible by ANGⅡ during renal sympathetic stimulation.
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